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The pancreas essentially produces two hormones for blood glucose control. These are glucagon in response to low blood glucose levels and insulin in response to high blood glucose levels.

The pancreas produces glucagon in response to low blood glucose levels. It is a linear polypeptide produced by the acini cells of the islets of langerhans.

This hormone allows glycogenolysis and gluconeogenesis to take place in the liver first and then muscle tissue. Glycogenolysis is the breakdown of glycogen to glucose which is then released into blood plasma to increase blood glucose levels. This occurs in the liver until glycogen stores in the liver are depleted and muscle glycogen stores are used. Gluconeogenesis is the synthesis of amino acids to form glucose which is then released into blood plasma to increase blood glucose levels. It also stimulates lypolysis which is the break down of fats.

The pancreas produces insulin in response to high blood glucose levels. It is also a polypeptide but is produced by the beta cells of the islets of langerhans. It increases cellular uptake of glucose which is removed from the blood, thus lowering blood glucose levels. This happens in most cells except the brain. It also fosters glycogen storage in the muscle and liver and promotes lipogenesis mainly in adipose tissue and the liver. It has one last effect. That is to stimulate protein synthesis from amino acids entering cells and inhibit protein degradation, effecting growth.

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