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Infantile spasms usually resolve with or without treatment in the majority of patients, generally by mid-childhood. However, other seizure types arise in 50-70% of patients

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What are infantile spasms?

Infantile spasms (IS) are seizures seen in epilepsy of infancy and early childhood


What is the main form of therapy for infantile spasms?

Antiepileptic medications are the mainstay of therapy for infants with infantile spasms


What factors are associated with a good prognosis from treatment of infantile spasms?

normal neurological exam and development at onset, absence of other seizure types at onset, older age of onset, short duration of spasms, and early effective treatment of spasms


Who first described infantile spasms?

Infantile spasms were first described by the English physician W.J. West (1794-1848) in 1841


What is the prognosis for intanfile spasams?

Intanfile spasms, also known as infantile spasms, typically have a variable prognosis depending on the underlying cause and the timeliness of treatment. Early diagnosis and intervention can lead to better outcomes, as prompt management often improves developmental trajectories. However, many children with infantile spasms may experience cognitive and developmental challenges, and some may have associated neurological disorders. Ongoing follow-up and tailored support are crucial for affected children and their families.


How are infantile spasms diagnosed?

The diagnosis of infantile spasms is made by a combination of the typical features, along with a characteristic electroencephalogram (EEG), which shows a very disorganized pattern termed hypsarrhythmia


What has the author Peter M Jeavons written?

Peter M. Jeavons has written: 'Photosensitive epilepsy' -- subject(s): Biological Photosensitization, Epilepsy 'Infantile spasms' -- subject(s): Infantile Spasms


What are the three subtypes of infantile spasms?

Flexor spasms involve flexion of the neck, trunk, and extremities. Extensor spasms consist of extension of the neck, trunk, and extremities


When do infantile spasms usually end?

Infantile spasms usually cease spontaneously by age five, but are often replaced by seizures of other types. Therefore, emphasis is placed on lifelong seizure prevention rather than recovery


How long do episodes of infantile spasms usually last?

In the United States, infantile spasms constitute 2% of childhood epilepsies, and 25% of epilepsies with onset in the first year of life. The rate of IS is 1.6-5.0 cases per 10,000 live births


What medical conditions can result in infantile spasms?

The number of neurological diseases that can result in infantile spasms is very large, but some of the major categories include intrauterine injury and infection, disorders caused by lack of blood flow to the fetal brain


What conventional anti-seizure drugs are sometimes used to treat infantile spasms?

Among conventional anti-seizure drugs, valproate and nitrazepam have been shown to be effective as first-line therapy. In addition to medication, there are some potential surgical options for infantile spasms