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The substantia nigra is best known for its production of dopamine, a major neurotransimitter used in certain cell populations in the brain. The most common link with respects to pathology, is in Parkinson's disease, where these cell populations (in the substantia nigra) die off, and the brain has very low amounts of dopamine to work with. Sorry I couldn't be more specific to the alzheimer's respects, but I'm just giving what I know. Take care.

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15y ago

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