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High levels of phosphorus in blood can occur in people with severe kidney disease or severe dysfunction of their calcium regulation. High phosphate levels in your blood reduce the formation of the active form of vitamin D (calcitriol) in your kidneys, reduce blood calcium, and lead to increased parathyroid hormone (PTH) release by the parathyroid glands.

High intakes of phosphorus, as is found in a diet with meats, soft drinks, and other convenience foods, can affect calcium metabolism. Because phosphorus is not as tightly regulated by the body as calcium, phosphate levels in your blood can rise slightly with a high phosphorus diet, especially after meals. If you drink too much soda and you don't eat enough leafy green vegetables and other calcium-rich foods, you are risking your bone health. Potential calcium deficiency symptoms may be more likely when your phosphorus intake is very high. A low calcium-to-phosphorus ratio in your diet increases your risk of hypertension and colon-rectal cancer. Excessively high levels of phosphorus in your blood can combine with calcium to form deposits in soft tissues such as muscle.

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