What is the role of the fibrillation?

Answer 1

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Fibrin is a protein substance that is synthesized by the liver and plays an essential role in blood clotting.

Fibrin is formed through polymerization and is the component of the clot, that stops the bleeding.

The doctor may recommend the fibrin test if the patient shows deficiencies in coagulation or if suffering from massive bleeding.

The normal values of fibrin in the blood: 200-400 mg per 100 ml of blood.

Decrease of fibrin levels mentioned above can cause bleeding in patients who have liver disease.

Fibrin increases, over values mentioned above, appear in acute Infectious Diseases and especially in rheumatic fever.

Relatively high levels of fibrin are occurring during pregnancy.

Answer 2

The formation of a blood clot (also known as a thrombus) is a key step in stopping bleeding after tissue injury. The adhesion of platelets to a blood vessel wall and their subsequent aggregation and activation are essential for thrombus formation.

Previous in vitro studies have shown that a protein known as vWF is essential for platelet adhesion, aggregation, and activation in thrombus formation. However, researchers from the Beth Israel Deaconess Medical Center, Boston, have now shown that vWF is not required for in vivo platelet activation in mice in which tissue injury was induced with a laser.In the study, which appears online in advance of publication in the April print issue of the Journal of Clinical Investigation, Bruce Furie and colleagues show that in mice lacking vWF, platelet activation (as measured by calcium mobilization) occurred normally following laser-induced injury, although platelet adhesion and aggregation were impaired. Platelet activation following laser-induced injury was shown to occur via the tissue factor-mediated pathway and not the collagen-mediated pathway. Therefore, this study indicates that, surprisingly, vWF is not required for in vivo tissue factor-mediated platelet activation, although other studies have indicated that it might have an in vivo role in collagen-mediated platelet activation.

Hope the answer will be useful for you!

Best regards, Aprelenko Oleg, Minsk (Belarus)

Answer 3

Fibrinogen is involved in blood clotting. It is converted by thrombin into its active form fibrin. Fibrin forms a mesh which traps red blood cells and platelets, forming the structural basis of a clot.

Answer 4

it combines with thrombin to produce fibrin. Fibrin then combines with blood cells to form the clotting of the blood

Answer 5

Fibrillation is caused by damage to the electrical system of the heart and can be deadly if untreated, it serves no role