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Replacement therapy is very effective in treating hemophilia. In the past 35 years the clotting factor concentrates have become better and safer to the point where a person with hemophilia has a near normal life expectancy, and many who use prophylaxis (preventative treatments) as their replacement therapy see little to no loss in their physical abilities or their quality of life.

Unfortunately a small percentage of the population develops what are known as inhibitors. Inhibitors are basically an immune response to the clotting factor protein. The antibodies can quickly wipe out the clotting factor making replacement therapy useless. Many of these rare individuals can successfully treat the inhibitor with what is termed Inhibitor Override Therapy. If override therapy works, replacement therapy should also become successful.

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