Iron deficiency anemia. The normal hematocrit (ratio of packed red blood cells to total blood volume) rules out anemia due to loss of blood cells through hemorrhage or sickling. Below-normal hemoglabin indicates an iron deficiency in this case. No available iron = no hemoglobin produced.
Congestive heart failure causes increased hemoglobin. When the underlying cause is anemia; the body will respond by increasing production of red blood cells (RBCs); withe a responding increase in hematocrit (the percentage of red blood cells in whole blood). Increased RBCs leads to increased hemoglobin levels.
It is increased. The lower air pressure in general leads to lower levels of oxygen and so the body compensates by making more red blood cells.
The equilibrium equation for sickle cell anemia can be represented in terms of the balance between normal hemoglobin (HbA) and abnormal hemoglobin (HbS). In individuals with sickle cell anemia, the presence of HbS leads to the sickling of red blood cells under low oxygen conditions. This can be expressed as: HbA + O2 ⇌ HbA-O2 (normal) and HbS + O2 ⇌ HbS-O2 (sickled). The equilibrium is influenced by factors such as oxygen saturation, pH, and hydration levels, affecting the overall health and symptoms of the individual.
When a person from sea level vacations in the Rocky Mountains, they may experience an increase in hematocrit levels. This is because the higher altitude results in lower oxygen availability, prompting the body to produce more red blood cells to enhance oxygen transport. Consequently, the increased red blood cell production leads to a higher concentration of red blood cells in the blood, reflected as elevated hematocrit levels.
There is no known direct link between anemia and sleep deprivation.
High hematocrit levels can be caused by various factors, including dehydration, which concentrates red blood cells due to reduced plasma volume. Other causes include chronic lung diseases, where low oxygen levels stimulate increased red blood cell production, and conditions like polycythemia vera, a bone marrow disorder that leads to excessive red blood cell production. Additionally, living at high altitudes can also increase hematocrit as the body adapts to lower oxygen availability.
Part of it is that kidneys produce erythropoetin, which is a hormone that stimulates red blood cell production in normal people. In kidney disease, this process is diminished. Also, it is thought that people with some chronic diseases develop what is called "anemia of chronic disease" and it's not clear how this is played out, but it leads to chronic anemia . Also, people with kidney disease are often fluid over-loaded, and may have a dilutional effect, where the hematocrit and hemoglobin concentration seems lower than it actually is due to so much fluid in the system. So it's likely due to a combination of the above reasons.
Increased hematocrit is the effect of living at high elevation. The human body compensates by increasing the volume of RBC in order to absorb as much oxygen on areas of high atmospheric pressure.
Clinically significant hemolysis is rare problem but it can affect red blood cell count and density of plasma. Studies have been done about the effect of hemolysis on hematocrit and the results stated that the changes appear too small to be accurately detected.
In very rare cases this combined affect is documented in the paper: "Identification of a SLC19A2 nonsense mutation in Persian families with thiamine-responsive megaloblastic anemia" by Setoodeh A et al 2013.
Megaloblastic (Macrocytic) Anemia. Basically the Red Blood Cells have a larger volume (MCV).
Aplastic anemia