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The standard of care for treatment of gout is a two-part or two-fold treatment. First, there is the need to reduce inflammation and pain during an acute attack. Non-steroidal anti-inflammatory drugs (or NSAIDs), such as acetominophen, naproxen and others, help to reduce inflammation and pain. (Aspirin should not be used.) Corticosteroids can be used when NSAIDs aren't doing enough.

Second, there is the need to reduce uric acid levels in the body, and excrete them. Allopurinol or probenicid helps to reduce uric acid levels (or the newer medicine, febuxostat). Uricosuric medications help to eliminate uric acid from the body (in the urine).

Finally, colchicine can be used to prevent flare-ups, and is to be taken chronically, for long-term treatment.

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