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Trauma (infringement or neglect/abandonment based, as there are two types). Specifically, the higher risk of debilitating symptoms will come not only from a emotional reactivity predisposition (diathesis-stress model), but also from a magnification factor kind of thing of the type of trauma. For instance, if it was pervasive, highly personal, and permanent (total loss of control) these will accelerate a "learned helplessness" response (a la Martin Seligman's theory) and accerbate the trauma effects and severity of the resulting PTSD.

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