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PLS affects a part of the neuron called the cell body (or soma). Specifically, it is the cell bodies of upper motor neurons that are affected.

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What are some of the better known motor neuron diseases?

Some of the better known motor neuron diseases include amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, spinal muscular atrophy (SMA), and primary lateral sclerosis (PLS). These diseases affect the motor neurons in the brain and spinal cord, leading to muscle weakness, atrophy, and impaired movement.


What causes primary lateral sclerosis?

Motor neuron diseases like primary lateral sclerosis develop because the nerve cells that normally control the movement of voluntary muscles degenerate and die.


Is Primary lateral sclerosis related to Lou Gehrig's Disease?

They are the same.


What part of the body is affected by primary lateral sclerosis?

The symptoms of the disorder become progressively worse, with muscles typically affected in the following order: legs and feet, main part of the body (the trunk), arms and hands, and face.


What is primary lateral sclerosis?

a rare disease that causes progressive weakness in voluntary muscles such as in the legs, hands, and tongue. PLS is one of the diseases, along with amyotrophic lateral sclerosis, that are grouped together as motor neuron diseases.


What is the average age of onset for primary lateral sclerosis?

The disease is typically detected in middle age, after age 50.


What specialists treat primary lateral sclerosis?

Treatment of PLS involves the family physician, a neurologist , and others such as physical therapists.


How deadly is primary lateral sclerosis?

PLS is not fatal, and people with the disorder can usually maintain mobility with the use of canes or other assistance.


What disease destroys the cells of the anterior gray horn?

Several diseases attack the motor neurons that have cell bodies located in the anterior horn of the spinal column namely: amyotropic lateral sclerosis, spinal muscular atrophies, primary lateral sclerosis, and Kennedy's disease (see the linked article for more detail).


How common is primary lateral sclerosis?

ALS is known to affect two to three people per 100,000. Tentative estimates of the occurrence of PLS are on the order of one person in 10 million


What are the motor system of the body?

Upper motor neuron cell bodies are situated in the motor cortex and project axons via the corticospinal tracts to the spinal cord. There they synapse in the anterior horn with lower motor neurons, which project axons via peripheral nerves that then contact muscle fibres at the neuromuscular junction. Lower motor neurons originating in the brain stem that control speech and swallowing (bulbar motor neurons), and lower motor neurons that originate in the spinal cord that control limb and respiratory muscles, may both be affected. Damage to various combinations of upper and lower motor neurons occurs in human amyotrophic lateral sclerosis.


What are the primary muscles targeted during lateral raises?

During lateral raises, the primary muscles targeted are the deltoid muscles, specifically the lateral deltoid.