What occurs when the immune system mounts a significant attack against the donated tissue?

Answer 1

The body triggers an immune reaction in response to a transplanted organ, since the recipient's body does not recognise the organ as part of itself. i.e the DNA of the transplanted organ, and the DNA of the person do not match (unless they are identical twins); the recipient's immune system reacts against the new DNA and attempts to 'kill it off'; similar to how the human immune system reacts to cold and 'flu virus' (which are made of something called RNA, not DNA) . This response is called "organ rejection"- the patient's body rejects the transplanted organ. Organ rejection is usually preventable by taking a type of drug called an "immunosuppressant".

Answer 2

Each cell in the human body has certain receptors (MHC also called HLA receptors) that will identify the cell as part of that body. Everybody has their own genes inherited from their mother and father to determine the form the receptors will be and therefore it is very rare to find two people with the same MHC receptors.

Your immune cells will be go around and bind to these receptors and if it does not recognize a receptor it will often initiate the destruction of the cell.

Since it is very difficult to find two people with identical MHC receptors often times for transplant they only require a certain percentage of similarity to be a match and even then it is rarely a 100% match. Therefore after the transplant if the difference between the transplanted organ MHC receptors and that of the receivers cells is too great the person's immune system will signal for the destruction of the transplanted cells.

Answer 3

Yes that is correct. So the recipient has to take anti rejection medication for the rest of their life.

Answer 4

organnelle system

Answer 5

Rejection Reaction occur

Answer 6

Rejection