Pretty much all of them. The lungs and airways are hardest hit, as they have to deal with the actual particles in the smoke, but then as the nicotine gets picked up by the bloodstream it gets carried to every part of your body.
There are many kinds of drugs, which are designed to affect many different organs, but there is no doubt that the one organ which is most often affected by drugs is the brain.
Heart
The liver is the most important organ affected in yellow fever.
The liver.
the target organ is the part of the body that is most adversely affected by exposure to a hazardous substance
The Heart
heart
Women seem to be somewhat more susceptible to smoking-related problems than men, but the difference is not great.
The liver. Most things "hepa-" are related to the liver.
Anencephaly is a birth defect where a baby is born without parts of the brain and skull. The brain is the organ most affected in anencephaly because it is either missing or severely underdeveloped. This condition is fatal in most cases, as the undeveloped brain cannot support life.
I think it would effect your lungs because you inhale the smoke
In areas where it is still common, children are most affected.