Pernicious Anemia has to do with your red blood cells lacking a strong count because of a great vitamin B12 deficiency, either some through some illness, infection or other cause that makes your stomach to be unable to absorb the necessary about of B12 from your food. So the part of the body this has to do with is your circulatory system, which in turn affects everything.
In the case of anemia, or pernicious anemia, this means that the white blood cells have outnumbered the red cells in the body, which would of course give the person a pale, unusually white appearance.
first of all its called vitamin b12 deficiency anemia. Pernicious anemia and vitamin B12 deficiency anemia are the same thing. Pernicious anemia is caused by a lack of vitamin B12. You're not able to absorb the vitamin B12 due to the absence of intrinsinc factor.
Megaloblastic (Macrocytic) Anemia. Basically the Red Blood Cells have a larger volume (MCV).
Perncious anemia is caused by the body's inability to absorb the vitamin B12 from the gastrointestinal tract, due to a loss of gastric parietal cells. Regular B12 supplementation can keep pernicious anemia at bay, though it is not a complete cure. B12 is a vitamin obtained from meat and dairy products.
Pernicious anemia can be treated with injections of vitamin B12, and possibly with B12 vitamin pills. Pernicious anemia is a vitamin B12 deficiency disease, B12 is required to make healthy red blood cells and can normally be obtained from animal based foods, including, meats, fish, dairy products and eggs (but not plant foods), however, when people choose not to eat animal products, vegans for instance, they may suffer a B12 deficiency. Also, inadequate absorption can occur when there is an insufficient amount of a specific protein referred to as "intrinsic factor" in the body that is normally released by stomach cells.
Pernicious Anemia has a lot to do with the red blood cells. You could do a search on the condition to see if this is what you're looking for.
Vitamin B12 deficiency anemia is another type of megaloblastic anemia that develops when the body doesn't absorb enough of this nutrient.
The different types of Anemia include: . Iron Deficiency Anemia - Is causes by blood loss, or lack of iron in the diet. . Pernicious Anemia - It occurs when the body is unable to absort Vitiman B12 . Folic Acid Deficiency Anemia - It occurs when there is a lack of folic acid in the diet. . Hemolytic Anemia - It is an inherited or acquired type of anemia that causes the red blood cells to be deformed, so the body breaks down the red blood cells too fast. . Sickle Cell Anemia - Inherited disease that occurs when the red blood cells are sickle shaped. The hemoglobin doesn't work right, the shape of the red blood cells causes them to clog the blood vessels and break down easily.
Intrinsic factor or gastric intrinsic factor is a protein produced by the stomach. It is used to absorb vitamin B12 in the small intestine. When there is a deficiency of the Intrinsic factor, there is a deficiency in the absorption of B12 into the body and this leads to pernicious anemia.
This is anaemia (lowered blood haemoglobin) due to a lack of vitamin B12 absorbed from the intestinal tract, due to a lack of intrinsic factor usually. This can be due to auto antibodies against the cells that produce intrinsic factor, stomach ulcers crowding out the cells that produce intrinsic factor, a hereditary lack of intrinsic factor or the after effects of surgery, illness or fish tapeworm. This gives a macrocytic anaemia. Pernicious anemia is an autoimmune disease that renders the person unable to absorb sufficient Vitamin B-12. Eventually the person becomes Vitamin B-12 deficient and must be treated. Prior to the availability of treatment persons died from the disease, hence the name pernicious. It is critical that treatment be obtained as soon as possible. You can find more information at the following website: www.pernicious-anaemia-society.org
The Schilling test is a definitive test for pernicious anemia. http://www.webmd.com/a-to-z-guides/schilling-test http://en.wikipedia.org/wiki/Schilling_test http://books.google.com/books?id=vCzlLiOlVeUC&pg=PA688&lpg=PA688&dq=definitive+test+for+pernicious+anemia&source=bl&ots=KLY8MXK4bu&sig=Tp8r9gNTXD8XXMbsWVHQZ47H1IQ&hl=en&ei=Jtm-ScLwIZGksQOfo6GoDA&sa=X&oi=book_result&resnum=5&ct=result http://medgadget.com/archives/2006/04/new_test_for_pe.html
Intrinsic factor is secreted by the parietal cells and is critical for absorption of B12. When the body attacks the parietal cells b12 deficiency results which is called "pernicious anemia."