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Opioids primarily affect the brain's reward system, particularly the areas involved in pleasure, motivation, and reinforcement, such as the nucleus accumbens and the ventral tegmental area. They bind to opioid receptors, which are densely located in these regions, leading to increased dopamine release and producing feelings of euphoria and pain relief. Additionally, opioids influence other brain areas involved in pain perception and emotional regulation, such as the thalamus and limbic system. This multifaceted effect contributes to their potent analgesic properties and potential for addiction.

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1mo ago

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