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Phencyclidine (PCP) primarily affects the glutamatergic system by antagonizing the NMDA (N-methyl-D-aspartate) receptors in the brain, which are crucial for synaptic plasticity and memory function. It also influences dopaminergic pathways, particularly in the mesolimbic system, which can lead to its characteristic psychoactive effects, including hallucinations and altered perceptions. Additionally, PCP has effects on other neurotransmitter systems, including serotonin and norepinephrine, contributing to its complex pharmacological profile.

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1mo ago

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