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Fatigue results from a combination of physiological processes, including the depletion of energy stores like glycogen in muscles, impaired neuromuscular function, and the accumulation of metabolic byproducts such as lactate. Additionally, central nervous system factors play a role, as neurotransmitter imbalances can affect motivation and perceived exertion. Inflammatory responses and hormonal changes, including increased levels of cortisol, can also contribute to feelings of fatigue. Collectively, these processes disrupt normal muscle function and energy production, leading to a sensation of tiredness or decreased performance.

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