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Down syndrome (trisomy 21) occurs when a gamete carrying an extra copy of chromosome 21 is involved in a fertilization event.


The gamete (whether sperm or oocyte) has an extra copy of chromosome 21 because of something called NONDISJUNCTION. This happens when a chromosome gets pulled to the wrong daughter cell.

This can happen either in meiosis I or meiosis II.

If nondisjunction happens in meiosis I, 2 gametes will be n+1 (have the extra copy of 21) and the other 2 gametes will be n-1 (will have NO copy of 21)

If nondisjunction happens in meiosis II, 2 gametes will be normal, one will be n+1 and one will be n-1.

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