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Lupus can affect virtually every body system. For some people, there is no organ involvement. 50% of people with lupus will have kidney disease. Lupus frequently affects the heart and lungs. Pericarditis and pleurisy are common. Lupus can affect the central nervous system causing seizures, headaches, and cognitive impairment. Involvement of other body systems is less common but does occur.

Lupus frequently occurs in overlap with other autoimmune conditions. In those cases, it is difficult to determine which disease is causing which damage.

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13y ago

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