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Our skin has two layers: (1) Epidermal layer and (2) Dermal layer.
Micro-organisms that penetrate through the epidermal layer is trapped in dermal layer which has WBC's, mast cells that fight antigen.
Dermal layer has two parts, papillary layer and dermis. Other processes in the dermis then gets rid of any waste collected in the papillary of epidermal layer.

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