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Despite many folk remedies and snake-oil salesman who would have you believe otherwise, only time can eliminate the hydrocodone and acetaminophen from your body to the point that it would not be detected by a drug screen. A person who has overdosed on Vicodin should be evaluated immediately by a physician, and may receive supportive care, narcotic antagonists, and/or the acetaminophen antidote. Note, however, that this does not eliminate the drugs from the body, but merely decreases their effect.

AM, Pharm. D., R.Ph.

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