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Schizophrenia, although it runs in families, is not a mutation, in the sense of something that has happened in a particular generation. It has been common throughout recorded history (although we used to call people who heard voices mystics, holy men or prophets).

Schizophrenia is caused by imbalances in brain chemistry, possibly by physical brain abnormalities in some rare cases, and occasionally may be either caused or triggered by physical or emotional trauma. Normal onset is in the late teens or early 20's, and it often self-ameliorates in late middle-age -- although by no means always.

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16y ago

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