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Tay-Sachs disease primarily affects individuals of Ashkenazi Jewish descent, with a higher carrier rate in this population. It can also occur in certain French Canadian, Cajun, and Irish communities. The disease is a genetic disorder caused by a deficiency of the Hex-A enzyme, leading to the accumulation of GM2 gangliosides in nerve cells. Generally, Tay-Sachs affects infants and young children, resulting in severe neurological impairment.

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