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The first successful kidney transplant between two twins. Proved that it was possible and aided in the understanding of 'rejection'.

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14y ago

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What 1954 development improved organ transplant succes?

The development of the anti suppressent drug Cylosporine by Dr.Callum Hume was the reason for the improvement in organ transplants in 1954.


Why were transplants between 1800 and 1954 not very successful?

If you're talking about organ transplants, it's because there were no anti-rejection drugs available on the market prior to this.


3 Transplants between 1800 and 1950 were not vey sucsessful Developments in 1954 resulted in an important breakthrough in transplant technniques?

1954 was when "organ rejection" was finally understood (one identical twin got a transplanted kidney from his other twin and lived happily ever after, sans organ rejection). Before then transplants were not successful due to lack of immunosuppresive drugs. The first good immunosuppressant (Ciclosporin)was developed in the 1970's, but rates did improve slightly after 1954 just through enhanced medical understanding.


Why were transplants not successful before 1954?

No effective immunosuppression, which is required to prevent organ rejection. Corticosteroids were available (which reduce inflammation), but no calcineurin inhibitors (such as ciclosporin or tacrolimus), which alter the function of T-cell lymphocytes (a type of white blood cell, produced by the patient's bone marrow, not the transplanted organ) to prevent organ rejection. Hence most transplants failed due to organ rejection pre-1954. The first effective immunosuppression (ciclosporin) was found in the 1970's, but 1954 happened to be the year when the process of organ rejection was first understood.


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erm the doctor


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Who Knew - 2010 Organ Transplants 5-46 was released on: USA: 16 December 2011


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three common concerns of the general public regarding transplants three common concerns of the general public regarding transplants


Successful Organ and tissue transplants since 1950?

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False.