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In the early 1900s, treatments for hyperthyroidism primarily included surgical intervention, such as thyroidectomy, where part or all of the thyroid gland was removed. Additionally, patients were often treated with radioactive iodine, which was introduced later in the 20th century but had early experimental uses. Antithyroid medications, like thiouracil, were also explored, though their use became more common in subsequent decades. Overall, the treatment options were limited and often involved invasive procedures.

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