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The neural activity progresses as if it were a wave (the effect moves but the nerve, of course does not). As the wave progresses it depolarizes the nerve surface, opens Na+ channels and activates the nerve surface as it goes forward. One effect of the firing however is that the Na+ channels inactivate and enter a refractory period in which they will not reopen. This essential drives the propagation wave in one direction only.

If the nerve were to be simultaneously stimulated at both ends the two waves would meet and then activity would cease. Neither wave would be able to overcome the refractory membrane that the other wave had passed over.

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17y ago

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