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There are many incompatible blood types depending on blood group and the antigens in them. A person given the wrong rH (antigen) factor could experience a severe, possibly life-threatening reaction. An immune response can trigger destruction of red blood cells releasing hemoglobin into the bloodstream. This also occurs in babies born to mothers of a different rH blood type.

A person with O- blood can receive only O-, and an O+ can only receive O. Almost anyone can receive O- blood. Other types follow the general +/- rules but with other restrictions.

The volume of the wrong blood transfused would be important. The assistant must pay attention to any abnormal reaction from the patient. Usually, during the initial infusion procedure, if the blood does not match, some reaction may appear, so the process must be halted immediately.

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