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Toothbrushes should be replaced as soon as the bristles show signs of wear, splay, fray or when the color indicator changes color. Generally, this is every 8 to 12 weeks. A worn toothbrush would not be able to clean as efficiently as a normal one.

http://www.intelligentdental.com/2010/02/22/are-you-brushing-your-teeth-away/

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