To minimize aerosol droplets when reconstituting and withdrawing chemotherapy from vials, it's essential to perform the procedure in a designated biological safety cabinet (BSC) to contain any potential aerosols. Use a syringe with a filter needle to draw up the medication gently, avoiding forceful aspiration. Additionally, always ensure that the vial is at room temperature and the reconstitution is done slowly to minimize agitation, which can create aerosols. Finally, wearing appropriate personal protective equipment (PPE) such as gloves, gowns, and masks is critical to protect against exposure.