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Emil Kraepelin (1856-1926), a German psychiatrist considered by many (includingHagop Akiskal M.D.) to be the father of the modern conceptualization of Bipolar disorder, categorized and studied the natural course of untreated bipolar patients long before mood stabilizers were discovered. Describing these patients in 1902, he coined the term "manic depressive psychosis." He noted in his patient observations that intervals of acute illness, manic or depressive, were generally punctuated by relatively symptom-free intervals in which the patient was able to function normally.

from http://en.wikipedia.org/wiki/History_of_bipolar_disorder

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