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It would depend on the source of the infection. That is why we see a doctor and/or have a throat culture taken. If it is not a bacterial infection (virus or yeast) than an antibiotic would not help and treating with antibiotics will delay proper treatment and may allow the infection to progress to a more serious stage. If it is bacterial, penicillin is the usual antibiotic unless the patient has a penicillin allergy or the doctor knows that penicillin is not appropriate for that type of bacteria.

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