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The allele responsible for sickle-cell anemia can be found on the short arm of chromosome 11, more specifically 11p15.
The sickle-cell disease occurs when the sixth amino acid, glutamic acid, is replaced by valine to change its structure and function. Sickle-cell anemia is also known as E6V.
Valine is hydrophobic, causing the hemoglobin to collapse on itself occasionally. The genetic disorder is due to the mutation of a single nucleotide, from a GAG to GTG codon on the coding strand, which is transcribed from the template strand into a GUG codon.
What else can I help you with?
Is sickle cell anemia an autoimmune disease?
Sickle Cell Anemia is Autosomal Recessive. It arises from a mutation on the beta-globin gene of chromosome 11. Because Sickle Cell Anemia is an example of incomplete dominance, a person has the disease if they have two mutated beta-globin genes but only has the trait (is a carrier) if they have only one mutated beta-globin gene.
Is sickle cell disease autosomal or x-linked or chromosomal?
Sickle cell disease is an autosomal recessive disorder, meaning that it is caused by a mutation in one of the autosomal chromosomes (chromosomes that are not sex chromosomes). In the case of sickle cell disease, the mutation occurs in the gene encoding the beta-globin subunit of hemoglobin on chromosome 11.
Is caused by a mutated allele that produces a defective form of the protein hemoglobin.?
False, Sickle Cell Disease :))
Hemophilia is caused by a mutated allele that produces a defective form of the protein hemoglobin?
False, Sickle Cell Disease :))
How is sickle cell trait different from sickle cell disease and what are the key distinctions between the two conditions?
Sickle cell trait and sickle cell disease are both genetic conditions caused by a mutation in the hemoglobin gene. Sickle cell trait means a person carries one copy of the mutated gene, while sickle cell disease means a person has two copies. The key distinction is that individuals with sickle cell trait usually do not experience symptoms, while those with sickle cell disease can have severe health issues such as pain crises, anemia, and organ damage.
The genetic disorder sickle cell disease is an example of heterozygous dominance?
Sickle cell disease is an example of codominance, not heterozygous dominance. In individuals who are heterozygous for the sickle cell allele, they exhibit a milder form of the disease called sickle cell trait, which demonstrates codominance of the normal and mutant hemoglobin alleles.
Is sickle cell anemia x-chromosome or non x-chromosome?
Sickle cell anemia is not sex linked.
Is sickle cell disease a blood cancer?
No, sickle cell disease is not cancerous.
Is you kiss do you get sickle cell disease?
No. Sickle Cell is not an infectious disease, but is genetic.
What are other names for sickle cell anemia?
Hemoglobin SS disease (Hb SS)
What chromosome number is affected in sickle cell disease?
Sickle cell disease is caused by a mutation on chromosome 11, specifically in the HBB gene that codes for the beta-globin protein. This mutation leads to the production of abnormal hemoglobin, resulting in the characteristic sickle-shaped red blood cells.
Is Sickle cell anemia inherited?
This is inherited on the X chromoseome and is recessive. This means a female (who has XX chromosome pair) can only express the disease if she carries the trait on both chromosomes. This is because of the recessive nature of the gene. A male can only inherit the disease from his mother. This is he must have obtained his Y chromosome from his father so he obtains the X chromosome from his mother. A male cannot carry the gene without expressing it as he doesnt have another X chromosome to supress the recessive gene. ^ This answer is biologically incorrect because Sickle cell Anemia is actually autosomal recessive, not sex-linked recessive; this means that males and females are affected equally and it is NOT carried on the X chromosome. In order for the trait to show up in an individual, BOTH parents must be carriers of the disease (at least 1 sickle cell gene must be present).
