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Which type of tissue would have a higher mitotic index normal tissue or cancerous tissue?
Cancer cells have higher mitotic index because they have a mutation in the DNA so they reproduce uncontrollably and therefore divide faster which means they have a higher mitotic index. ex. In a normal lung tissue, % of cells dividing is 5% while in a cancerous lung the % of cells divding is 25 %
Why would the mitotic index be relevant to a diagnosis of breast cancer?
Because cancer is uncontrolled mitosis of cells; thus if the mitotic index of the breast cells in question is outside the normal range (above it, generally), then this would suggest increased rate of cell proliferation which could indicate cancer.
Is the percentage of cells in the resting stage is higher in cancerous cells than normal cells?
No, cancer cells are more active than normal cells. Cancer cells are always dividing at a faster rate than normal cells.
What is a mitotic lesion?
A mitotic lesion is an abnormality in a cell that affects its ability to divide properly during mitosis. This can lead to errors in chromosome segregation and potentially result in genetic mutations or cell death. Mitotic lesions are associated with conditions such as cancer and developmental disorders.
Which specific cytoskeletal element is most susceptible to mitotic inhibitors?
Microtubules are the specific cytoskeletal elements most susceptible to mitotic inhibitors. These inhibitors, such as taxanes and vinca alkaloids, disrupt the normal function and dynamics of microtubules during cell division, leading to mitotic arrest. By interfering with the formation of the mitotic spindle, these drugs effectively halt the proliferation of cancer cells.
What does bladder cancer do to the normal cells?
Bladder cancer will force normal cells to divide uncontrollably.
How are cancerous cells and noncancerous cells the same?
In non-cancer cells, disorazole C1 induced a prolonged mitotic arrest, followed by mitotic slippage, as confirmed by live cell imaging and cell cycle analysis. This mitotic slippage was associated with cyclin B degradation, but did not require p53. Four assays for apoptosis, including western blotting for poly(ADP-ribose) polymerase cleavage, microscopic analyses for cytochrome C release and annexin V staining, and gel electrophoresis examination for DNA laddering, were conducted and demonstrated little induction of apoptosis in non-cancer cells treated with disorazole C1. On the contrary, we observed an activated apoptotic pathway in cancer cells, suggesting that normal and malignant cells respond differently to disorazole C1. Our studies demonstrate that non-cancer cells undergo mitotic slippage in a cyclin B-dependent and p53-independent manner after prolonged mitotic arrest caused by disorazole C1. In contrast, cancer cells induce the apoptotic pathway after disorazole C1 treatment, indicating a possibly significant therapeutic window for this compound
What is mitotic lesion?
A mitotic lesion is one in which there is an increased rate of mitosis in cells. This can be indicative of cancer where there is abnormal proliferation of cells.
Do cancer cells divide at a faster rate than normal cells?
Yes, cancer cells typically divide at a faster rate than normal cells.
What are the differences between normal cells and cancer cells in terms of their characteristics and behavior?
Normal cells and cancer cells differ in several ways. Normal cells have a controlled growth and division rate, while cancer cells grow uncontrollably. Normal cells have a specific function in the body, while cancer cells lose their specialized function. Additionally, normal cells undergo programmed cell death when necessary, but cancer cells evade this process. Finally, normal cells have a limited ability to spread to other parts of the body, while cancer cells can invade nearby tissues and metastasize to distant organs.
One difference between a cancer cell and a normal cell is that?
a. cancer cells divide uncontrollably. b. normal cells cannot make copies of DNA. c. cancer cells cannot make copies of DNA. d. normal cells divide uncontrollably. (A) cancer cells divide uncontrollably
Do cancer cells have a long or short interphase?
In the cell cycle of cancer cells interphase is still the longest phase. However, interphase is shorter in cancer cells than in normal cells.
