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Lyme Disease, which is caused by Borrelia Burgdorferi, does not fit Koch's postulates for a few reasons; Bb genetically changes inside the host so when it is cultured to be re-introduced to a new healthy animal, virulence factors might have changed; certain strains of the bacteria isolated from different patients may not be the same so growing a pure culture will not have the same results in every experiment.

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12y ago

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