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They allow the virus to circumvent defenses that have been created by hosts to prevent the virus from attaching to and taking over the host cells (a first step in the Lytic Cycle of viral infection and replication). Because the flu viruses can mutate quickly and frequently, many hosts are not able to continue to defend against them with production of new antibodies fast enough to prevent an infection by a mutation of the original infecting virus.

The hosts that the flu viruses have infected create antibodies that disable the virus' ability to attach to and enter their cells by perfectly fitting into and blocking the proteins on the outer surface (capsid) of the virus. The proteins are what allow viruses to attach to and enter a host cell and begin the replication process. Genetic mutations in the virus that vary the shapes of these proteins on the capsid of the next generation allow the virus to foil the host's ability to perfectly fit and block the attachment to host cells.

See also the related questions below for more information about the Lytic Cycle of viral replication.

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Related Questions

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