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A decrease in neutrophils and an increase in lymphocytes can occur due to various factors, such as infections, stress, or immune responses. Neutrophils often decline in viral infections or after prolonged inflammation, while lymphocytes, particularly T and B cells, can increase to fight off viral pathogens. Additionally, certain medical treatments, like chemotherapy or corticosteroids, can suppress neutrophil production while stimulating lymphocyte activity. This shift reflects the body's adaptive immune response to different types of challenges.

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