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Even though clubbing is a widely recognized symptom of many diseases the physiological mechanism that actually causes clubbing is not well understood. Current understanding is that these diseases cause http://www.answers.com/topic/vasodilator in the distal circulation which leads to http://www.answers.com/topic/organ-hypertrophy of the tissue of the nailbeds and thus to the clubbed fingernails. Other factors that have been implicated are the local effects of growth factors (such as http://www.answers.com/topic/platelet-derived-growth-factor and http://www.answers.com/topic/hepatocyte-growth-factor) that are usually sequestrated in the pulmonary capillary bed. Many of the conditions associated with clubbing result in shunting across some of the capillary beds in the pulmonary circulation.


http://www.answers.com/clubbing See the Related Links for "The aetiology of clubbing and hypertrophic osteoarthropathy." to the bottom for the answer.

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