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During pregnancy, levels of several essential coagulation factors increase.There are marked increases in fibrinogen and factor8. Factors VII, IX, X, and XII also increased but to a lesser extend.

Fibrinolytic activity is depressed during pregnancy and labor, although the precise mechanism is unkown. The placenta may be partially responsible for this alteration in fibrinolytic status. Plasminogen levels increase concomitantly with fibrinogens levels, causing an equilibration of clotting and lysing activity.

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