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COPD is characterized by aveolar destruction. Funstional alveoli are necessary for the transport of oxygen from the atmosphere into the blood stream and eventually to the tissues. Loss of alveoli equals loss of oxygen in the tissues and incidently increase in carbon dioxide in the same since it cannot be excreted into the lungs. The end consumer of oxygen is the target tissue. The tissue merely registers that oxygen levels are low, but cannot differentiate as to whether they are low for lack of oxygen transport capacity or lack of oxygen to be transported. Hemoglobin is a molecule that binds oxygen in the bloodstream. It is responsible for the delivery of a majority of the oxygen that reaches the target tissue. Since an organism is not necessarily able to alter the external environment that it is in, i.e. the oxygen that is available to it, it attempts to increase it's ability to transport the oxygen that is available, i.e., it increases the concentration of hemoglobin in it's bloodstream. Hope that this helps. PTR

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