In the lungs where the oxygen concentration is high the binding of oxygen tohemoglobin is high. In respiring tissue where the oxygen levels are low and the CO2 levels are high the affinity of hemoglobin for oxygen is reduced and so the oxygen comes off the hemoglobin and is used by the cells. The driving force for this is the Bohr Effect whereby CO2 produced by the respiring cells dissolves in the blood as follows
CO2 + CO2 --> H2CO3 --> H+ + HCO3-. The H+ produced bind to the hemoglobin and in doing so displace the oxygen
The oxygen is carried by Hemoglobin to the Tissues! What happens is, that there's something called the Allosteric Inhibition! Which means, when the Hemoglobin reaches the tissue, there will be lots of Co2 released in the tissue, during release of energy, the partial pressure of co2 inside the tissue will be high, so that with pressure gradient, it will travel outside the tissue to the artery and then into the hemoglobin where it binds to different sites and when that happens, it allosterically inhibits the Hemoglobin molecule to let go of Oxygen, and the oxygen is bounded as per cooperativity which means when one oxygen is bounded it will be easier for others to get bound to it, and in the same way when co2 attaches itself to the Hemoglobin, the oxygen start to disassociate as the Hemoglobin changes its shape and once one oxygen molecule leaves the hemoglobin it would be harder for the molecule to hold on to the rest of the 3 molecules! So in such way the oxygen leaves the hemoglobin!
The Bohr effect and cooperative binding of oxygen to hemoglobin is what makes it an effective carrier of oxygen from the lungs to the peripheral tissues. What is cooperative binding? The first oxygen bind less strongly to oxygen then does the subsequent oxygen molecules (hemoglobin has four binding zones for oxygen). This means that the binding curve is fairly steep. The Bohr effect is a negative effect on binding of oxygen by hemoglobin in the presence of increased pH. Since peripheral tissues release C02 it increases the local pH releasing the oxygen. After the first oxygen is released the remaining oxygen molecules are quickly disassociated from hemoglobin thus delivering the oxygen to the tissue in need of oxygen.
Blood id the tissue that carries oxygen to cells in body . Blood is a liquid connective tissue . It possess RBC which contain hemoglobin . Hemoglobin binds with oxygen and transports it .
In the lungs, oxygen saturation of hemoglobin is close to 100% due to high oxygen levels in alveoli. In exercising tissue, oxygen saturation can drop to around 70-75% as oxygen is released to supply energy for muscle contraction.
help in transportation of the red blood cell through oxygen to the lungs then to the tissue
This is called the Bohr effect where a increase in pC02 which decrease the pH leads to a decreased affinity of hemoglobin to oxygen. This means that hemoglobin unloads oxygen in areas where pC02 is high e.g. active tissue and that the binding coefficient of hemoglobin is highest in the lung where pC02 is negligible.
Carbon monoxide binds to hemoglobin in red blood cells with a higher affinity than oxygen, forming carboxyhemoglobin. This reduces the amount of hemoglobin available to bind oxygen, leading to decreased oxygen delivery to tissues.
Carbon monoxide blocks the transport of oxygen in the body by binding to hemoglobin, forming a stable complex that reduces the ability of hemoglobin to carry oxygen to tissues. This can lead to hypoxia and potentially result in tissue damage or organ failure.
Red blood cells, which are a component of blood, carry oxygen throughout the body. They contain hemoglobin, a protein that binds to oxygen and transports it to various tissues and organs.
Hemoglobin is the compound in red blood cells that carries oxygen from the lungs to body cells. The oxygen combines readily with the ion in hemoglobin, and hemoglobin can carry more than twenty times its own volume in oxygen. After releasing oxygen to the cells, hemoglobin collects carbon dioxide and carries it to the lungs where it is exhaled.
Myoglobin and hemoglobin are structurally similar proteins, with around 20% sequence similarity. They both contain heme groups that bind oxygen, but hemoglobin is found in red blood cells and is responsible for transporting oxygen, while myoglobin is found in muscle tissue and is involved in storing and transporting oxygen within muscles.
ABG (Arterial Blood Gases) is a measurement of oxygen saturation in the arterial blood which supplies oxygenated blood to the body tissue and the extraction of oxygen from the hemoglobin at the capillary level. The amount of oxygen saturation of the hemoglobin (HbO2) depends on hemoglobin concentration and the arterial pressure often referred to as Hemoglobin / O2 dissociation curve. At lower body temperature, less oxygen is bounded to hemoglobin, while at higher temperature slightly more oxygen is bounded to hemoglobin. It is therefore important to know the body temperature when the ABG analysis is done so as to have a more meaningful interpretation of the result.