Why does hemophilia does not follow the classic mendelian rule?

Answer 1

Hemophilia does not follow classic Mendelian inheritance patterns because it is an X-linked recessive disorder. This means that the gene responsible for hemophilia is located on the X chromosome, and males, having only one X chromosome, are more likely to express the condition if they inherit the affected allele. In contrast, females have two X chromosomes, so they would need to inherit two copies of the mutated gene to exhibit the disorder, making hemophilia less common in females. This results in a characteristic inheritance pattern that diverges from Mendelian ratios typically seen in autosomal traits.