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The cyclical pattern of malaria symptoms (fever, chills, fever, chills) is due to the time-regulated bursting of merozoites from red blood cells. The merozoites (a stage in the malaria parasite's development), burst from red blood cells in a cyclical pattern at a time which is specific to the species of malaria parasite. The fever is the body's immune response to the sudden high concentration of merozoites in the bloodstream. The chills are due to the invasion of new red blood cells by the merozoites.

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Why shivering occurs in case of malaria until a person is suffering from high fever?

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