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Bird flu primarily targets the lower respiratory system due to the presence of specific receptors in the cells of the trachea and lungs that are more compatible with the virus. These receptors, known as avian-type sialic acid receptors, are more abundant in the lower respiratory tract, allowing the virus to efficiently enter and infect those cells. In contrast, the upper respiratory system has different receptor types that are less suited for avian influenza viruses, which may explain the virus's limited impact in that area.

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2mo ago

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