In dengue fever, the liver is affected due to the virus's ability to replicate within liver cells, leading to inflammation and damage. The immune response to the infection can also contribute to liver injury, as the body releases cytokines that can exacerbate inflammation. This hepatic involvement may result in elevated liver enzymes and, in severe cases, contribute to complications such as liver failure. Monitoring liver function is important in managing dengue patients.
Dengue virus primarily affects immune cells, particularly macrophages and dendritic cells, which are key components of the immune response. The virus can also impact endothelial cells lining blood vessels, leading to increased vascular permeability and contributing to symptoms like bleeding and plasma leakage. Additionally, liver cells may be affected, resulting in liver dysfunction in severe cases. Overall, the systemic nature of dengue can lead to widespread tissue involvement.
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In dengue patients, elevated levels of serum glutamate-pyruvate transaminase (SGPT) and serum glutamate-oxaloacetate transaminase (SGOT) are often indicative of liver involvement, which can occur due to direct viral invasion of liver cells or as a result of immune-mediated liver injury. The release of these enzymes into the bloodstream is a response to liver cell damage, which can be exacerbated by factors such as hypoxia, dehydration, and coagulopathy associated with severe dengue. Monitoring these enzyme levels helps assess the severity of liver impairment and overall disease progression in dengue patients.
In past 2-3 years India was affected by the Dengue the most .
Dengue fever primarily affects humans and is transmitted by the Aedes mosquito. There is no evidence to suggest that animals can contract dengue fever.
Delhi
Liver
The liver is most affected.
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liver
Liver