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Isoniazid is a first line anti-tubercular drug which is used in treatment of tuberculosis.

Pyridoxine is the naturally occurring form of vitamin B6. Following absorption from the gastrointestinal tract, it is converted in the liver to a coenzyme, pyridoxal phosphate, that is involved in many metabolic processes. Isoniazid interferes competitively with pyridoxine metabolism by inhibiting the formation of the active form of the vitamin, and hence often results in peripheral neuropathy.

Hence, to prevent peripheral neuropathy, pyridoxine 10mg/day is given prophylactically to patients along with anti-tubercular treatment.

Patients with evidence of vitamin B6 deficiency may require doses upto 50mg/day.

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