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Regional inflammation of the skin is typically very painful due to the release of inflammatory mediators, such as prostaglandins and histamines, which sensitize nerve endings. This heightened sensitivity leads to increased pain perception in the affected area. Additionally, the swelling and redness associated with inflammation can put pressure on surrounding tissues, further exacerbating the pain. The body's protective response to injury or infection is aimed at promoting healing, but it often results in significant discomfort.

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1w ago

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