During dialysis, urea, creatinine, excess electrolytes (such as potassium or sodium), and excess fluid are some of the solutes that typically diffuse from the patient's blood into the dialysis solution.
the concentration of urea should be kept low in the dialysis fluid because urea is harmful for our body if it is not removed.
Urea passes through the dialysis tubing into the dialysis fluid due to the process of diffusion, where molecules move from an area of higher concentration to an area of lower concentration. The dialysis tubing is semi-permeable, allowing small molecules like urea to cross while retaining larger molecules and cells. As urea accumulates in the blood and reaches a higher concentration than in the dialysis fluid, it diffuses out to achieve equilibrium. This process helps remove waste products from the blood in dialysis treatments.
urea
urea and excess salts
A dialysis machine tries to mimic some of the functions of a human kidney. One of the primary jobs of a kidney is to remove urea and certain salts from the blood so they can exit the body in urine. In a dialysis machine, blood from the patient runs through tubes made of a semi-porous membrane. Outside the tubes is a sterile solution made up of water, sugars and other components. Red and white blood cells and other important blood components are too large to fit through the pores in the membranes, but urea and salt flow through membranes into the sterile solution and are removed.
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The isotonic solution for Urea would be a solution that has the same osmotic pressure as a cell. This concentration would typically be around 0.15 M for Urea.
The concentration of urea in a patient's blood rises between dialysis treatments due to the accumulation of waste products, primarily nitrogenous wastes, that the kidneys can no longer effectively filter out. In patients with kidney failure, the kidneys lose their ability to excrete urea and other toxins, leading to their buildup in the bloodstream. Dialysis temporarily removes these wastes, but between sessions, they reaccumulate as the body continues to produce them. Thus, the levels of urea and other waste products fluctuate, peaking just before the next dialysis treatment.
Distilled water will move out of the dialysis bag and into the sucrose solution due to osmosis and the fact that the dialysis bag has a hypertonic solution of H2O as compared to the sucrose solution.
Dialysis fluid is hypotonic to facilitate the movement of waste products and excess electrolytes from the blood into the dialysis fluid while minimizing the loss of essential proteins and cells. A hypotonic solution has a lower concentration of solutes compared to the blood, which encourages the diffusion of toxins and urea out of the blood, helping to purify it. This osmotic gradient is crucial for effective dialysis treatment in patients with kidney failure.
The dialysis fluid is different to plasmas in that it does not have the uric acid and urea in it.. besides that- it has no excess salts either.