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gallbladder stones, obstruct the flow of the pancreatic enzymes. since cholecystokinins helps activate the bile from the gallbladder, once it is obstructed, the cholecystokinins, activates the pancreatic enzymes as well causing enzymes to become activated inside the pancreatic tissues then auto-digestion takes place(pancreatic enzymes ingests itself), in a normal functioning pancreas, enzyme has to remain inactive until it reaches the small intestine, where an actual digestion takes place.

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