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Pethidine, also known as meperidine, can cause tachycardia primarily due to its anticholinergic effects, which inhibit the action of the neurotransmitter acetylcholine. This inhibition can lead to increased heart rate as the parasympathetic nervous system's control over heart rate is diminished. Additionally, pethidine can cause the release of histamine, which may also contribute to cardiovascular effects, including increased heart rate.

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2mo ago

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