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Platelets are non-nucleated because they are actually fragments of larger cells called megakaryocytes, which are found in the bone marrow. During their formation, the megakaryocytes undergo a process called endomitosis, where they replicate their DNA without cell division, resulting in large cells that then release small cytoplasmic fragments into the bloodstream. This lack of a nucleus allows platelets to be more flexible and specialized for their primary functions in hemostasis and clot formation. Additionally, their non-nucleated nature contributes to their short lifespan, as they lack the machinery for protein synthesis and cellular repair.

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1mo ago

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