If by "shut down" you mean "die," then yes.
The brain would begin to shut down from lack of oxygen, you would suffer irreparable brain damage in the early stages of this, then your entire body would begin to shut down without a stable brain to control it. Your heart would slow down untill it com
Probably the circulatory system because the heart would start pumping unfiltered blood(blood that has no oxygen) and then the brain wouldn't get the oxygen it needed and you could die.
No oxygen at all? Yes. This is because certain types of blood cells carries oxygen to your brain. If your brain has no oxygen, it will shut down, and, as a result, so will the rest of your body.
Your brain just shuts down and all your body follows your brain
The brain requires oxygen to generate the energy it needs to operate. Blood provides the necessary oxygen transport. Blocking the arteries would starve the brain of oxygen and the brain would rapidly start shutting down. Starve it of oxygen long enough (about one minute) and cells stop functioning properly and even start dying, escalating rapidly to whole brain death. This is not a healthy thing to do. Do not try this at home.
The cardiovascular system pumps essential nutrients and oxygen to all of your cells. without your cardiovascular system your cells would start to die, and your brain and other organs would shut down because of the lack of oxygen.
it would change by the oxygen going low down
nerves
nerves
The brain becomes deprived of oxygen when the creature depending on the brain fails to breathe. This can be reversed with quick medical attention; otherwise everything shuts down and the creature dies. Similarly if the air you are breathing is short of oxygen as in high altitude or with the use of gas mixtures such as nitrous oxide. with some of these situations it feel like you are breathing but you are in fact suffocating and causing damage to the brain.
Oxygen is transported first by air down the trachea and then transform to the hemoglobin of the blood to the cells. This is the pathway of oxygen in the human system.
Your brain only makes up roughly 3% of your total body mass and yet it consumes more than 20% of the total oxygen used by your body. A telling fact, indeed, is that your brain's consumption of the oxygen content in your bloodstream sees a noticeable increase during times of mental activities such as studying and sustained concentration. Essentially, your brain uses oxygen as food! In order to continue to function effectively your brain must have high enough levels of oxygen delivered via your bloodstream. Whether that oxygen comes from oxygen therapy, supplements, some form of medical treatment, or the atmosphere, your brain needs it to continue effectively ensuring healthy functioning of the body. Bad memory, lack of concentration, bad balance; these are all side effects of your brain not getting enough oxygen from your bloodstream. Consider it; whenever you exercise, your breathing rate increases. This is because each and every cell in your body -- your brain included -- requires the elevated level of oxygen from your blood in order to produce the energy levels required to function at peak perfor